Practically, it is impossible to make a perfect vacuum. A perfect vacuum is defined as a region in space
without any particles.

The problem is that to maintain a vacuum in a region you have to shield it from the
environment. It is not difficult to make a container that would prevent atoms from entering
the region.

The first problem is that the container itself will radiate photons (which in turn can create electron positron pairs in the vacuum) if it is not kept at a
temperature of 0'K. Note that a perfect vacuum has by definition a temperature of 0'K.
reaching 0 'K is practically impossible.

The second problem is that there are weakly interacting particles that could enter the
region. No matter how thick the walls of the container are, there is always a finite
probability that, say, a neutrino would enter the region.
Answered by: Saibal Mitra, M.S., Physics Grad Student, UVA Amsterdam

'A theory with mathematical beauty is more likely to be correct than an ugly one that fits some experimental data. God is a mathematician of a very high order, and He used very advanced mathematics in constructing the universe.'